Doxylamine succinate is eliminated somewhat more slowly from the body than diphenhydramine hydrochloride. A single dose causes rapid and marked drowsiness in the vast majority of individuals. Diphenhydramine is the active ingredient in Sleep Eze, Sominex, Nytol, Tylenol PM, and Unisom SleepGelsĭoxylamine succinate is one of the most sedating antihistamines available over-the-counter (stronger than diphenhydramine).Since its use is associated with less of a hangover effect, and is milder than doxylamine, it is usually a good first choice in this category of and OTC sleep aid. In general, diphenhydramine is less expensive than doxylamine. Tolerance to this particular antihistamine builds up quickly and it loses its effectiveness as a sleep aid after just a few nights of repeated use. Also, these sleep medications may interact negatively with other medications, so a doctor should be consulted prior to using these for a sleeping problem.ĭiphenhydramine is eliminated quickly from the body and most individuals don’t experience any lingering grogginess from the medicine the next day. Many over-the-counter sleep aids can result in the person feeling groggy and unwell the next day. Tolerance to the sedative effects of antihistamines can develop quickly-the longer they are taken the less likely they are to induce sleep. If patients attempt to use an OTC sleep aid, they should immediately discontinue use if they experience any adverse side effects such as: The OTC sleep medications rely on the sedating effects of the antihistamine to facilitate sleep. See Using Medication to Manage Pain and Reduce Sleep Problems According to the American Academy of Sleep Medicine, antihistamine (usually diphenhydramine hydrochloride or doxylamine succinate) is the most common ingredient in OTC sleep aids. OTC sleep medications should only be used on a short term basis, since extended use of these medications can actually exacerbate insomnia. Examples of popular over-the-counter sleep aids include: Over-the-counter medications for the treatment of a sleep problem are those that can be purchased without a prescription.
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